2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-D1631A
    Calcium green-5N hexapotassium 153130-66-6
    Calcium green-5N hexapotassium is a cell-impermeant Ca2+-sensitive fluorescent probe. Calcium green-5N hexapotassium shows enhancement in fluorescence intensity on binding Ca2+, and can monitor free Ca2+ in neurons.
    Calcium green-5N hexapotassium
  • HY-D2844A
    FITC-PEG1000-FA 98%
    FITC-PEG1000-FA is a fluorescent dye composed of Folic acid (HY-16637) (FA), polyethylene glycol (PEG) and FITC (HY-66019). Fluorescent dye is linked to PEG and Folic acid through a specific chemical reaction to form a molecule with special properties. FITC-PEG1000-FA can be used for fluorescent labeling and imaging.
    FITC-PEG1000-FA
  • HY-D2844C
    FITC-PEG3400-FA 98%
    FITC-PEG3400-FA is a fluorescent dye composed of Folic acid (HY-16637) (FA), polyethylene glycol (PEG) and FITC (HY-66019). Fluorescent dye is linked to PEG and Folic acid through a specific chemical reaction to form a molecule with special properties. FITC-PEG3400-FA can be used for fluorescent labeling and imaging.
    FITC-PEG3400-FA
  • HY-D2844D
    FITC-PEG5000-FA 98%
    FITC-PEG5000-FA is a fluorescent dye composed of Folic acid (HY-16637) (FA), polyethylene glycol (PEG) and FITC (HY-66019). Fluorescent dye is linked to PEG and Folic acid through a specific chemical reaction to form a molecule with special properties. FITC-PEG5000-FA can be used for fluorescent labeling and imaging.
    FITC-PEG5000-FA
  • HY-D2844E
    FITC-PEG10000-FA 98%
    FITC-PEG10000-FA is a fluorescent dye composed of Folic acid (HY-16637) (FA), polyethylene glycol (PEG) and FITC (HY-66019). Fluorescent dye is linked to PEG and Folic acid through a specific chemical reaction to form a molecule with special properties. FITC-PEG10000-FA can be used for fluorescent labeling and imaging.
    FITC-PEG10000-FA
  • HY-DY1024
    TPE-MI (solution) 1245606-71-6
    TPE-MI (Tetraphenylethene maleimide) (solution) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm). TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasitesPlasmodium falciparum .
    Solvent and concentration: DMSO: 10 mM
    TPE-MI (solution)
  • HY-DY1045
    Methoxy-X04 (solution) 863918-78-9
    Methoxy-X04 (solution) is a fluorescent dye that crosses the blood-brain barrier and selectively binds to beta-pleated sheets found in dense core amyloid Aβ plaques. Methoxy-X04 retains in vitro binding affinity for amyloid b (Ab) fibrils (Ki= 26.8 nM). Methoxy-X04 is fluorescent and stains plaques, tangles, and cerebrovascular amyloid in postmortem sections of AD brain with good specificity.
    Solvent and concentration: DMSO: 5 mg/mL
    Methoxy-X04 (solution)
  • HY-DY1056
    Texas Red (solution) 60311-02-6
    Texas Red (Sulforhodamine 101) (solution) is an amphoteric rhodamine red fluorescent dye (excitation/emission: 586/605 nm). Texas Red is used extensively for investigating neuronal morphology and acts as acell type-selective fluorescent marker of astrocytes bothin vivoand in slice preparations.
    Solvent and concentration: DMSO: 10 mM
    The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
    Texas Red (solution)
  • HY-E70049
    beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) 67338-98-1
    beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) (GM2/GD2 synthase) is a key enzyme which catalyzes the conversion of GM3, GD3 and lactosylceramide (LacCer) to GM2, GD2 and asialo-GM2 (GA2), respectively. beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) is a key enzyme to control the synthesis of brain-enriched complex gangliosides.
    beta-1,4-N-Acetylgalactosaminyltransferase (CgtA)
  • HY-E70149
    ST6 Gal Sialyltransferase 2
    ST6 Gal Sialyltransferase 2 (EC:2.4.3.1, ST6GAL2) catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. ST6 Gal Sialyltransferase 2 plays an important role in schizophrenic research.
    ST6 Gal Sialyltransferase 2
  • HY-E70172
    Heparan Sulfate 3-O-Sulfotransferase 4 98%
    Heparan Sulfate 3-O-Sulfotransferase 4 is a sulfotransferase. Heparan Sulfate 3-O-Sulfotransferase 4 regulates Notch signaling.
    Heparan Sulfate 3-O-Sulfotransferase 4
  • HY-E70294
    N-Acetylgalactosaminyltransferase 13
    N-Acetylgalactosaminyltransferase 13 (GALNT13) is a glycosaminyltransferase. N-Acetylgalactosaminyltransferase 13 participates in neuronal differentiation by glycosylating and stabilizing PDPN.
    N-Acetylgalactosaminyltransferase 13
  • HY-E70305
    GlcNAc-1-Phosphotransferase 84012-69-1 98%
    GlcNAc-1-Phosphotransferase is an α2β2γ2 hexamer with core catalytic α- and β-subunits derived from GNPTAB. GlcNAc-1-Phosphotransferase catalyzes the addition of the il group of N-acetylglucosamine-1-phosphate to the terminal mannose. Mutations in GlcNAc-1-Phosphotransferase cause lysosomal storage disorders such as mucolipidosis.
    GlcNAc-1-Phosphotransferase
  • HY-E70395
    Prolyl endopeptidase 72162-84-6
    Prolyl Endopeptidase, highly active in brain and other tissues, catabolizes proline-containing peptides such as substance P, neurotensin, luteinizing hormone-releasing hormone, thyrotropin releasing hormone, bradykinin and angiotensin II. Prolyl Endopeptidase can be used for study of neuropsychiatric diseases such as stress disorder, depression, and schizophrenia.
    Prolyl endopeptidase
  • HY-E70410
    NAD Synthetase 9032-69-3 98%
    NAD synthetase is responsible for the final step in the synthesis of nicotinamide adenine dinucleotide (NAD). The Km values for NAD, ATP, and ammonia of NAD synthetase from Escherichia coli are 200 μM, 11 μM, and 0.65 μM, respectively, while the Km values for NAD, ATP, and ammonia of NAD synthetase from yeast are 170 μM, 190 μM, and 64 μM, respectively. NAD synthetase can be used for enzymatic assays to determine ATP, ammonia, urea, or creatinine, and is also suitable for enzymatic cycling methods. Additionally, NAD synthetase holds potential for research into metabolic diseases, cancer, aging, and neurodegenerative diseases.
    NAD Synthetase
  • HY-E70627
    Ubiquitin thiolesterase UCHL1
    Ubiquitin thiolesterase UCHL1 (EC 3.1.2.15) is a member of the ubiquitin carboxy-terminal hydrolase family of deubiquitinating enzymes. Ubiquitin thiolesterase UCHL1 functions as an ubiquitin ligase and a mono-ubiquitin stabilizer.
    Ubiquitin thiolesterase UCHL1
  • HY-E70632
    PIP5K1B Recombinant Human Active Lipid Kinase
    PIP5K1B participates in the biosynthesis of PI(4,5)P2. PIP5K1B is at the crossroad of different signaling pathways, mediating RAC1-dependent reorganization of actin filaments and contributing to the activation of phospholipase D2. PIP5K1B Recombinant Human Active Lipid Kinase can be used for the study of Friedreich’s ataxia (FRDA).
    PIP5K1B Recombinant Human Active Lipid Kinase
  • HY-E70633
    PIP5K1C Recombinant Human Active Lipid Kinase
    PIP5K1C Recombinant Human Active Lipid Kinase is a phosphatidylinositol 4-phosphate 5-kinase (PIP5K) with nociceptive sensitization. PIP5K1C Recombinant Human Active Lipid Kinase can be used to study the role of PIP5K1C in nociceptive signaling and sensitization.
    PIP5K1C Recombinant Human Active Lipid Kinase
  • HY-E70657
    CDK10/CycQ Recombinant Human Active Protein Kinase
    CDK10/CycQ Recombinant Human Active Protein Kinase is a cyclin-dependent kinase, which is important for neural development and can act as a tumour suppressor.
    CDK10/CycQ Recombinant Human Active Protein Kinase
  • HY-E70665
    CDK17/CycY Recombinant Human Active Protein Kinase
    CDK17 is highly expressed in terminally differentiated neurons, particularly those found in hippocampal regions and olfactory bulbs. CDK17/CycY Recombinant Human Active Protein Kinase is an ortholog of CDK17.
    CDK17/CycY Recombinant Human Active Protein Kinase
Cat. No. Product Name / Synonyms Application Reactivity